02191nam a2200265 4500 NALT 20251110115329.0 251106b th ||||| |||| 00| 0 eng d NALT RC 918.N45 N66C 2023 Noppanan Kotsaouppara. 66915 Characterization of nephrotoxicity of damnacanthal in nude mice model / Noppanan Kotsaouppara. Bangkok : Thammasat University, 2023. 93 p. : ill., tables, chart ; 30 cm. Chapter 1 Introduction -- Chapter 2 Objectives -- Chapter 3 Review of literature -- 3.1 Nephrotoxicity -- 3.2 Nephrotoxicity induced by anthraquinone -- 3.3 Mechanisms of nephrotoxicity -- 3.4 The mouse grimace scale -- 3.5 General background of Damnacanthal -- Chapter 4 Materias and methods -- 4.1 Experimental outline -- 4.2 Preliminary experiment -- 4.3 Animal experiment -- 4.4 Blood chemistry evaluation -- 4.5 Gastrointestinal hemorrhage investigation -- 4.6 Urinalysis evaluation -- 4.7 Histopathology examination -- 4.8 Immunohistochemistry examination -- 4.9 Quantitative area percentage -- 4.10 Statistical analysis -- Chapter 5 Results -- 5.1 Monitoring of DAM20 and Veh treated nude mice during the study -- 5.2 Ultrasonic renal examination for physiology assessment -- 5.3 Urinalysis of DAM20 and Veh treated nude mice -- 5.4 Hematology and Blood chemistry evaluation of DAM20 and Veh treated nude mice -- 5.5 Histopathology examination of mice treated with high doses of damnacanthal -- 5.6 Histopathology examination of mice treated with repeated doses of DAM20 -- 5.7 Assessment of apoptosis and infiltrated macrophage subtype by immunohistochemistry in renal tissue of mice treated with damnacanthal -- Chapter 6 Discussion -- Chapter 7 Conclusion. Kidney drug effects 66936 Damnacanthal Toxicology 66937 Kidney Diseases drug therapy 66938 Kidney diseases in animals 66939 lcc RSH jidapa.t ACQSTF 2025-11-06 varee.k LIBSTF 2025-11-07 jamriang.p CATSTF 2025-11-10 107437 107437 1020 นางจำเรียง ระวังสำโรง 0 0 lcc 0 0 CRSH NALT NALT RSH 2025-11-06 0 Res RC 918.N45 N66C 2023 3961215821 2025-11-06 00:00:00 2025-11-06 RSH